Simplifying the generation of insight from protein structures
Nelson Perdigão1,2, Agostinho Rosa1,2, Seán I. O’Donoghue3
Updated: June 2016
This indicates when the Dark Proteome Database (DPD) was last calculated.
PDB structures released since then are not yet available in DPD.
1. University of Lisbon, Portugal
2. Instituto de Sistemas e Robótica, Lisboa, Portugal
3. Garvan Institute of Medical Research, Sydney, Australia
Annotations from the UniProt database include organism, subcellular location, tissue specificity, function, domains, and motifs;
Secondary structure is considered from the PDB whenever available;
Known interactors with evidence in databases and literature are taking into account.
PSSH2 homology database aligns 550.116 Swiss-Prot into 119.475 PDB generating ~ 49M 3D models;
We use Predict Protein to predict secondary structure, disordered and trans-membrane domains.
We use Protein Model Portal models to validate and complement PSSH2 sequence-structure alignments.
© Copyright 2015-2020 Nelson Perdigão and ISR-IST-ULisboa, All Rights Reserved.