About Dark Proteome Database  

DPD

Simplifying the generation of insight from protein structures

Nelson Perdigão1,2, Agostinho Rosa1,2, Seán I. O’Donoghue3

Updated: June 2016
This indicates when the Dark Proteome Database (DPD) was last calculated.
PDB structures released since then are not yet available in DPD.

1. University of Lisbon, Portugal
2. Instituto de Sistemas e Robótica, Lisboa, Portugal
3. Garvan Institute of Medical Research, Sydney, Australia



Q9H324 - 1-234 - Dark | 9606

Sequence:

MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRS

Length: 234

Number of Swiss-Prot Features: 10

Swiss-Prot Features

variant in WMS1_1,,A -> T (in WMS1; shows consistent and significantly diminished protein secretion). {ECO:0000269|PubMed:18567016}. /FTId=VAR_054439.,,25:25;
signal_1,,{ECO:0000255},,1:25;
chain_1,,A disintegrin and metalloproteinase with thrombospondin motifs 10. /FTId=PRO_0000029185.,,234:234;
compbias_1,,Poly-Pro,,58:61;
propep_1,,{ECO:0000250} /FTId=PRO_0000029184.,,26:233;
variant_2,,T -> S (in dbSNP:rs7255721) {ECO:0000269|PubMed:15355968}. /FTId=VAR_054441.,,134:134;
variant_1,,R -> Q (in dbSNP:rs3814291) /FTId=VAR_054440.,,119:119;
carbohyd_2,,N-linked (GlcNAc...). {ECO:0000255},,222:222;
carbohyd_1,,N-linked (GlcNAc...). {ECO:0000255},,90:90;
var_seq_1,,MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEI AFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVAS PSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARPHCL YAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGG PKGSRSPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGR PWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVV ADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNIL VTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHG NAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGM CERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCG ARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGL CLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKY GEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYK RVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHC DSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSE FDSIPFRGKFYKWKTYRGGGVK -> MGPTSVLRAGLTPSC LPPPSGATNGSVSPLGRAQRVWTEPGGRGLHGATAAGPVAA ACPLLAVTATAPGQPSGASTVWVREGGTAPATRMTVPLAPR TSEKCSVLNLTASLSVGNSTSGKRTGE (in isoform 2). {ECO:0000305}. /FTId=VSP_054707.,,1:234;

Predicted Transmembrane Helixes (Predict Protein):

Predicted Transmembrane Beta Barels (Predict Protein):

Predicted Disorder Sections (Predict Protein): 60-68, 165-169, 199-202, 214-231,

Q9H324 - 235-820 - White | 9606

Sequence:

VSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIA

Length: 586

Number of Swiss-Prot Features: 29

Swiss-Prot Features

conflict_1,,AT -> PQ (in Ref. 2; AAG35563) {ECO:0000305}.,,385:386;
conflict_2,,S -> N (in Ref. 2; AAG35563) {ECO:0000305}.,,437:437;
disulfid_4,,{ECO:0000250},,409:436;
carbohyd_4,,N-linked (GlcNAc...). {ECO:0000255},,740:740;
disulfid_11,,{ECO:0000250},,574:586;
disulfid_2,,{ECO:0000250},,351:358;
domain_2,,Disintegrin,,460:546;
conflict_3,,C -> S (in Ref. 2; AAG35563) {ECO:0000305}.,,643:643;
disulfid_8,,{ECO:0000250},,521:536;
domain_3,,TSP type-1 1. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,547:602;
disulfid_1,,{ECO:0000250},,315:376;
carbohyd_3,,N-linked (GlcNAc...). {ECO:0000255},,323:323;
compbias_2,,Poly-Ser,,568:571;
disulfid_3,,{ECO:0000250},,370:452;
metal_2,,Zinc; catalytic. {ECO:0000250},,396:396;
compbias_3,,Cys-rich,,604:705;
disulfid_7,,{ECO:0000250},,496:531;
disulfid_9,,{ECO:0000250},,559:596;
metal_1,,Zinc; catalytic. {ECO:0000250},,392:392;
carbohyd_5,,N-linked (GlcNAc...). {ECO:0000255},,795:795;
act_site_1,,{ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095}.,,393:393;
chain_1,,A disintegrin and metalloproteinase with thrombospondin motifs 10. /FTId=PRO_0000029185.,,235:820;
disulfid_10,,{ECO:0000250},,563:601;
var_seq_1,,MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEI AFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVAS PSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARPHCL YAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGG PKGSRSPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGR PWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVV ADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNIL VTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHG NAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGM CERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCG ARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGL CLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKY GEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYK RVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHC DSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSE FDSIPFRGKFYKWKTYRGGGVK -> MGPTSVLRAGLTPSC LPPPSGATNGSVSPLGRAQRVWTEPGGRGLHGATAAGPVAA ACPLLAVTATAPGQPSGASTVWVREGGTAPATRMTVPLAPR TSEKCSVLNLTASLSVGNSTSGKRTGE (in isoform 2). {ECO:0000305}. /FTId=VSP_054707.,,235:637;
metal_3,,Zinc; catalytic. {ECO:0000250},,402:402;
disulfid_5,,{ECO:0000250},,479:501;
domain_1,,Peptidase M12B. {ECO:0000255|PROSITE-ProRule:PRU00276}.,,239:457;
region_1,,Spacer,,706:820;
disulfid_6,,{ECO:0000250},,490:508;

Predicted Transmembrane Helixes (Predict Protein):

Predicted Transmembrane Beta Barels (Predict Protein): 357-364,

Predicted Disorder Sections (Predict Protein):

Q9H324 - 821-825 - Dark | 9606

Sequence:

RDSLP

Length: 5

Number of Swiss-Prot Features: 3

Swiss-Prot Features

domain_4,,TSP type-1 2. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,825:825;
chain_1,,A disintegrin and metalloproteinase with thrombospondin motifs 10. /FTId=PRO_0000029185.,,821:825;
region_1,,Spacer,,821:825;

Predicted Transmembrane Helixes (Predict Protein):

Predicted Transmembrane Beta Barels (Predict Protein):

Predicted Disorder Sections (Predict Protein):

Q9H324 - 826-869 - White | 9606

Sequence:

PYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAH

Length: 44

Number of Swiss-Prot Features: 3

Swiss-Prot Features

region_1,,Spacer,,826:828;
domain_4,,TSP type-1 2. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,826:869;
chain_1,,A disintegrin and metalloproteinase with thrombospondin motifs 10. /FTId=PRO_0000029185.,,826:869;

Predicted Transmembrane Helixes (Predict Protein):

Predicted Transmembrane Beta Barels (Predict Protein):

Predicted Disorder Sections (Predict Protein):

Q9H324 - 870-871 - Dark | 9606

Sequence:

SK

Length: 2

Number of Swiss-Prot Features: 2

Swiss-Prot Features

domain_4,,TSP type-1 2. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,870:871;
chain_1,,A disintegrin and metalloproteinase with thrombospondin motifs 10. /FTId=PRO_0000029185.,,870:871;

Predicted Transmembrane Helixes (Predict Protein):

Predicted Transmembrane Beta Barels (Predict Protein):

Predicted Disorder Sections (Predict Protein):

Q9H324 - 872-917 - White | 9606

Sequence:

LPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSA

Length: 46

Number of Swiss-Prot Features: 4

Swiss-Prot Features

domain_5,,TSP type-1 3. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,884:917;
domain_4,,TSP type-1 2. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,872:883;
chain_1,,A disintegrin and metalloproteinase with thrombospondin motifs 10. /FTId=PRO_0000029185.,,872:917;
carbohyd_6,,N-linked (GlcNAc...). {ECO:0000255},,892:892;

Predicted Transmembrane Helixes (Predict Protein):

Predicted Transmembrane Beta Barels (Predict Protein): 904-910,

Predicted Disorder Sections (Predict Protein): 872-872, 917-917,

Q9H324 - 918-921 - Dark | 9606

Sequence:

AEEK

Length: 4

Number of Swiss-Prot Features: 2

Swiss-Prot Features

domain_5,,TSP type-1 3. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,918:921;
chain_1,,A disintegrin and metalloproteinase with thrombospondin motifs 10. /FTId=PRO_0000029185.,,918:921;

Predicted Transmembrane Helixes (Predict Protein):

Predicted Transmembrane Beta Barels (Predict Protein):

Predicted Disorder Sections (Predict Protein):

Q9H324 - 922-988 - White | 9606

Sequence:

ALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPA

Length: 67

Number of Swiss-Prot Features: 3

Swiss-Prot Features

domain_6,,TSP type-1 4. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,947:988;
chain_1,,A disintegrin and metalloproteinase with thrombospondin motifs 10. /FTId=PRO_0000029185.,,922:988;
domain_5,,TSP type-1 3. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,922:945;

Predicted Transmembrane Helixes (Predict Protein):

Predicted Transmembrane Beta Barels (Predict Protein):

Predicted Disorder Sections (Predict Protein):

Q9H324 - 989-989 - Dark | 9606

Sequence:

A

Length: 1

Number of Swiss-Prot Features: 2

Swiss-Prot Features

domain_6,,TSP type-1 4. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,989:989;
chain_1,,A disintegrin and metalloproteinase with thrombospondin motifs 10. /FTId=PRO_0000029185.,,989:989;

Predicted Transmembrane Helixes (Predict Protein):

Predicted Transmembrane Beta Barels (Predict Protein):

Predicted Disorder Sections (Predict Protein):

Q9H324 - 990-1045 - White | 9606

Sequence:

KPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEAL

Length: 56

Number of Swiss-Prot Features: 3

Swiss-Prot Features

domain_7,,TSP type-1 5. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,1003:1045;
domain_6,,TSP type-1 4. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,990:1001;
chain_1,,A disintegrin and metalloproteinase with thrombospondin motifs 10. /FTId=PRO_0000029185.,,990:1045;

Predicted Transmembrane Helixes (Predict Protein):

Predicted Transmembrane Beta Barels (Predict Protein):

Predicted Disorder Sections (Predict Protein):

Q9H324 - 1046-1047 - Dark | 9606

Sequence:

RP

Length: 2

Number of Swiss-Prot Features: 2

Swiss-Prot Features

domain_7,,TSP type-1 5. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,1046:1047;
chain_1,,A disintegrin and metalloproteinase with thrombospondin motifs 10. /FTId=PRO_0000029185.,,1046:1047;

Predicted Transmembrane Helixes (Predict Protein):

Predicted Transmembrane Beta Barels (Predict Protein):

Predicted Disorder Sections (Predict Protein):

Q9H324 - 1048-1059 - White | 9606

Sequence:

PTTQQCEAKCDS

Length: 12

Number of Swiss-Prot Features: 2

Swiss-Prot Features

domain_7,,TSP type-1 5. {ECO:0000255|PROSITE-ProRule:PRU00210}.,,1048:1058;
chain_1,,A disintegrin and metalloproteinase with thrombospondin motifs 10. /FTId=PRO_0000029185.,,1048:1059;

Predicted Transmembrane Helixes (Predict Protein):

Predicted Transmembrane Beta Barels (Predict Protein):

Predicted Disorder Sections (Predict Protein): 1049-1053,

Q9H324 - 1060-1103 - Dark | 9606

Sequence:

PTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCHGH

Length: 44

Number of Swiss-Prot Features: 3

Swiss-Prot Features

domain_8,,PLAC. {ECO:0000255|PROSITE-ProRule:PRU00233}.,,1065:1103;
chain_1,,A disintegrin and metalloproteinase with thrombospondin motifs 10. /FTId=PRO_0000029185.,,1060:1103;
conflict_4,,H -> Q (in Ref. 2; AAG35563) {ECO:0000305}.,,1101:1101;

Predicted Transmembrane Helixes (Predict Protein):

Predicted Transmembrane Beta Barels (Predict Protein):

Predicted Disorder Sections (Predict Protein): 1065-1065,





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